Telmisartan (TEL) is having poor and pH-dependent water solubility. The present study describes the preparation of binary and ternary solid dispersions of TEL designed to improve its dissolution profile in water. The solvent evaporation method was used for the preparation of solid dispersions. The effect of incorporation of alkalizers (magnesium carbonate, dibasic calcium phosphate dihydrate, and sodium citrate dihydrate) on the properties TEL solid dispersions (SD) in polyethylene glycol 6000 (PEG6000) has been investigated. The physicochemical properties of the various SD systems were determined by Differential Scanning Calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), and Powder X-ray Diffraction Spectroscopy (PXRD). The results from dissolution studies, performed according to the USP II paddle method, indicated that the ternary SD containing magnesium carbonate as the alkalizer significantly (P<0.01) increased the drug dissolution rate in water and phosphate buffer (pH 7.4) as compared to TEL alone. It was evident that the magnesium carbonate in PEG6000 based SDs synergistically enhanced dissolution of TEL by changing drug crystallinity towards an amorphous form via molecular interactions.
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